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Synfacts 2006(10): 1035-1035  
DOI: 10.1055/s-2006-949279
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart · New York

Rh-Catalyzed Asymmetric Transfer Hydrogenation in Aqueous Media

Contributor(s): Mark Lautens, Yann Béthuel
D. S. Matharu, D. J. Morris, G. J. Clarkson, M. Wills*
University of Warwick, Coventry, UK
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Publication History

Publication Date:
21 September 2006 (online)

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Significance

In the present paper, Wills et al. report a new catalyst for Rh-mediated asymmetric transfer hydrogenation in aqueous solution and formic acid/triethylamine. This catalyst is prepared using their previously developed tethered ligand (Org. Lett. 2005, 7, 5489-5491) with introduction of a core N-tosyl-1,2-diaminocyclohexane structure (K. Murata, T. Ikariya, R. Noyori J. Org. Chem. 1999, 64, 2186-2187). Improved stability as well as high catalytic activity (up to 0.01 mol%) were noted both in formic acid/triethylamine and in aqueous media.