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Synfacts 2006(10): 1023-1023  
DOI: 10.1055/s-2006-949319
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart · New York

Palladium-Catalyzed Allylic Alkylation

Contributor(s): Hisashi Yamamoto, Joshua P. Abell
K. H. Kim, C.-K. Jeong, D.-H. Kim, D.-C. Ha*
Korea University, Seoul, Korea
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Publikationsdatum:
21. September 2006 (online)

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Significance

Asymmetric allylation using palla­dium has been known to occur with high yields and enantioselectivities using various P,P- and N,P-ligands. Utilizing a binaphthyl steric backbone as a source of chirality, the authors found that the homologation of their previously synthesized NOBIN (2-amino-2′-hydroxyl-1,1′-binaphthyl) showed better reactivity and stereoselectivity.