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Synfacts 2006(10): 0984-0984  
DOI: 10.1055/s-2006-949337
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart · New York

Synthesis of (-)-Cubebol

Contributor(s): Philip Kocienski, John Cooksey
C. Fehr*, J. Galindo
Firmenich SA, Genève, Switzerland
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Publication History

Publication Date:
21 September 2006 (online)

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Significance

(-)-Cubebol is a flavouring agent isolated from the berries of Piper cubeba. Fehr and Galindo report a diastereoselective synthesis of (-)-cubebol using a metal-catalyzed cyclo­isomerization of an enynol ester. For a related concurrent synthesis of (-)-α-cubebene, (-)-cubebol and sesquicarene, see: A. Fürstner, P. Hannen Chem. Eur. J. 2006, 12, 3006-3019.