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Synfacts 2006(10): 0994-0994  
DOI: 10.1055/s-2006-949344
Synthesis of Heterocycles
© Georg Thieme Verlag Stuttgart · New York

Synthesis of Tetrahydropyrido[4,3-d]pyrimidines from 4-Piperidinone

Contributor(s): Victor Snieckus, Todd Macklin
A. Herrera, R. Martínez-Alvarez*, R. Chioua, J. Almy
Universidad Complutense, Madrid, Spain, Université Abdelmalek Essaâdi, Tétouan, Morocco and California State University, Turlock, USA
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Publication History

Publication Date:
21 September 2006 (online)

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Significance

The current report describes a straightforward and facile route to a class of new tetrahydropyrido[4,3-d]pyrimidine derivatives via the reaction of 1-benzylpiperidin-4-one with an alkyl/aryl cyanide or thiocyanate in the presence of triflic anhydride. The reported conversion of the methylthio derivatives into methoxy and uracil systems via 1 represents further useful chemistry.