Synfacts 2006(10): 0991-0991  
DOI: 10.1055/s-2006-949355
Synthesis of Heterocycles
© Georg Thieme Verlag Stuttgart · New York

Synthesis of Fluoropyridines from 4-(2-Fluoroallyl)oxazolones

Contributor(s): Victor Snieckus, Wei Gan
U. Wittmann, F. Tranel, R. Fröhlich, G. Haufe*
Westfälische Wilhelms-Universität Münster, Germany
Further Information

Publication History

Publication Date:
21 September 2006 (online)

Significance

The synthesis of polysubstituted 4-fluoropyridines from fluorinated amino acid allylic esters involving successive Ireland-Claisen (A) and aza-Cope (B) rearrangements of oxazolone derivatives in modest yields is reported. None of the intermediates suggested in the mechanism shown could be isolated although an analogous species to the carbene (C) has been trapped with dimethyl acetylenedicarboxylate (J. Fischer, W. Steglich Angew. Chem., Int. Ed. Engl. 1979, 18, 167-168). 4-Methyl oxazolones do not lead to fluoropyridine derivatives.