Abstract
This account describes the development of methyleneaziridines as heterocyclic building blocks for a variety of useful synthetic transformations including multicomponent reactions, cycloadditions and radical cascades.
1 Introduction
2 Preparation of Methyleneaziridines
2.1 Ring Closure to Methyleneaziridines
2.2 Functionalization of Methyleneaziridines
3 Multicomponent Reactions
3.1 Ketone-Forming MCRs
3.2 Amine- and Heterocycle-Forming MCRs
3.3 α-Amino Nitrile Forming MCRs
4 [4+3] Cycloadditions
5 Radical Rearrangements
6 Conclusions
Key words
aziridines - strained heterocycles - ring opening
References and Notes
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