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Synfacts 2007(2): 0121-0121  
DOI: 10.1055/s-2006-955755
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart · New York

Synthesis of Adociacetylene B

Contributor(s): Philip Kocienski, Indu Dager
B. M. Trost*, A. H. Weiss
Stanford University, USA
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Publication History

Publication Date:
23 January 2007 (online)

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Significance

Adociacetylene B inhibits the reverse transcriptase of HIV. A short and highly efficient enantioselective synthesis of both (+)- and (-)-adociacetylene A is reported that utilizes a double asymmetric zinc alkynylation.