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Synfacts 2007(2): 0120-0120  
DOI: 10.1055/s-2006-955766
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart · New York

Synthesis of Pseudolaric Acid A

Contributor(s): Philip Kocienski, Fiona Black
Z. Geng, B. Chen, P. Chiu*
The University of Hong Kong, P. R. of China
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Publication History

Publication Date:
23 January 2007 (online)

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Significance

Pseudolaric acid A is an active component of tujinpi which is a herb used in traditional Chinese medicine for the treatment of derma­tological fungal infections. The key step in the synthesis of the perhydroazulene skeleton is an intramolecular carbene-cyclization-cycloaddition cascade (CCCC) reaction.