General Preparation of Amines by Oxidative Coupling of Amidocuprates

Significance

Substituted anilines and heterocyclic amines are important intermediates and target molecules in organic synthesis. The herein reported method allows the preparation of a broad range of mono-, di- and triaryl and heteroaryl­amines, including those bearing a halide group or very bulky substituents, which are difficult to prepare by common Pd-catalyzed amination techniques. Primary, secondary and tertiary amines are readily available by this protocol with excellent functional group compatibility.