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Int J Sports Med 2008; 29(3): 182-187
DOI: 10.1055/s-2007-965114
Physiology & Biochemistry

© Georg Thieme Verlag KG Stuttgart · New York

IGF‐I and IGFBP-3 during Continuous and Interval Exercise

J. L. Copeland1 , L. Heggie1
  • 1Department of Kinesiology, University of Lethbridge, Lethbridge, Canada
Further Information

Publication History

accepted after revision January 9, 2007

Publication Date:
13 September 2007 (online)

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Abstract

The purpose of this research was to compare changes in circulating levels of total IGF‐I and IGFBP-3 during continuous, moderate-intensity exercise (CE) and high-intensity interval exercise (IE) of equal duration. Ten healthy males completed 2 exercise sessions and a resting control session (R) in random order. The CE was 20 minutes of cycling at 60 - 65 % of V·O2max. During IE, subjects cycled at 80 - 85 % of V·O2max for 1 minute followed by 40 seconds of active recovery, with the cycle repeated for a total of 20 minutes. In each session blood samples were drawn at - 10, 0, 5, 10, 20 and 30 minutes. Both IGF‐I and IGFBP-3 increased during exercise (p < 0.05) and repeated measures ANOVA revealed a significant effect for session (IE, CE > R, p < 0.05). Area under the curve (AUC) analyses showed no difference in IGF‐I between sessions, however, the IGFBP-3 AUC was significantly greater during IE than R (p < 0.05). These results suggest interval and continuous exercise will result in similar changes in circulating IGF‐I and IGFBP-3. This could be beneficial to individuals who can exercise longer and at a higher intensity in intervals than would be possible using a continuous protocol.

Key words

exercise intensity - insulin‐like growth factor‐I - insulin‐like growth factor binding protein‐3 - interval exercise - cycling

References

  • 1 Adams G R, Haddad F. The relationships among IGF‐1, DNA content, and protein accumulation during skeletal muscle hypertrophy.  J Appl Physiol. 1996;  81 2509-2516
    PubMedSearch in Google Scholar
  • 2 Bang P, Brandt J, Degerblad M, Enberg G, Kaijser L, Thoren M, Hall K. Exercise-induced changes in insulin-like growth factors and their low molecular weight binding protein in healthy subjects and patients with growth hormone deficiency.  Eur J Clin Invest. 1990;  20 285-292
    PubMedSearch in Google Scholar
  • 3 Baumgartner R N, Waters D L, Gallagher D, Morley J E, Garry P J. Predictors of skeletal muscle mass in elderly men and women.  Mech Ageing Dev. 1999;  107 123-136
    CrossrefPubMedSearch in Google Scholar
  • 4 Berg U, Bang P. Exercise and circulating insulin-like growth factor I.  Horm Res. 2004;  62 (Suppl 1) 50-58
    PubMedSearch in Google Scholar
  • 5 Bonnefoy M, Kostka T, Patricot M C, Berthouze S E, Mathian B, Lacour J R. Physical activity and dehydroepiandrosterone sulphate, insulin-like growth factor I and testosterone in healthy active elderly people.  Age Ageing. 1998;  27 745-751
    CrossrefPubMedSearch in Google Scholar
  • 6 Brahm H, Piehl-Aulin K, Saltin B, Ljunghall S. Net fluxes over working thigh of hormones, growth factors and biomarkers of bone metabolism during short lasting dynamic exercise.  Calcif Tissue Int. 1997;  60 175-180
    CrossrefPubMedSearch in Google Scholar
  • 7 Cappola A R, Bandeen-Roche K, Wand G S, Volpato S, Fried L P. Association of IGF‐I levels with muscle strength and mobility in older women.  J Clin Endocrinol Metab. 2001;  86 4139-4146
    CrossrefPubMedSearch in Google Scholar
  • 8 Cappon J, Brasel J A, Mohan S, Cooper D M. Effect of brief exercise on circulating insulin-like growth factor I.  J Appl Physiol. 1994;  76 2490-2496
    PubMedSearch in Google Scholar
  • 9 Chadan S G, Dill R P, Vanderhoek K, Parkhouse W S. Influence of physical activity on plasma insulin-like growth factor-1 and insulin-like growth factor binding proteins in healthy older women.  Mech Ageing Dev. 1999;  109 21-34
    CrossrefPubMedSearch in Google Scholar
  • 10 Crewther B, Keogh J, Cronin J, Cook C. Possible stimuli for strength and power adaptation: acute hormonal responses.  Sports Med. 2006;  36 215-238
    CrossrefPubMedSearch in Google Scholar
  • 11 Dall R, Lange K H, Kjaer M, Jorgensen J O, Christiansen J S, Orskov H, Flyvbjerg A. No evidence of insulin-like growth factor-binding protein 3 proteolysis during a maximal exercise test in elite athletes.  J Clin Endocrinol Metab. 2001;  86 669-674
    CrossrefPubMedSearch in Google Scholar
  • 12 Donath M Y, Jenni R, Brunner H P, Anrig M, Kohli S, Glatz Y, Froesch E R. Cardiovascular and metabolic effects of insulin-like growth factor I at rest and during exercise in humans.  J Clin Endocrinol Metab. 1996;  81 4089-4094
    CrossrefPubMedSearch in Google Scholar
  • 13 Eliakim A, Oh Y, Cooper D M. Effect of single wrist exercise on fibroblast growth factor-2, insulin-like growth factor, and growth hormone.  Am J Physiol. 2000;  279 R548-R553
    PubMedSearch in Google Scholar
  • 14 Friedenreich C M, Orenstein M R. Physical activity and cancer prevention: etiologic evidence and biological mechanisms.  J Nutr. 2002;  132 3456S-3464S
    PubMedSearch in Google Scholar
  • 15 Frystyk J, Nyholm B, Skjaerbaek C, Baxter R C, Schmitz O, Orskov H. The circulating IGF system and its relationship with 24-h glucose regulation and insulin sensitivity in healthy subjects.  Clin Endocrinol (Oxf). 2003;  58 777-784
    CrossrefPubMedSearch in Google Scholar
  • 16 Goldspink G, Harridge S D. Growth factors and muscle ageing.  Exp Gerontol. 2004;  39 1433-1438
    CrossrefPubMedSearch in Google Scholar
  • 17 Hornum M, Cooper D M, Brasel J A, Bueno A, Sietsema K E. Exercise-induced changes in circulating growth factors with cyclic variation in plasma estradiol in women.  J Appl Physiol. 1997;  82 1946-1951
    PubMedSearch in Google Scholar
  • 18 Jackson A, Pollock M. Practical assessment of body composition.  Phys Sportsmed. 1985;  13 76-90
    PubMedSearch in Google Scholar
  • 19 Jenkins P J, Bustin S A. Evidence for a link between IGF‐I and cancer.  Eur J Endocrinol. 2004;  151 (Suppl 1) S17-S22
    CrossrefPubMedSearch in Google Scholar
  • 20 Jones J I, Clemmons D R. Insulin-like growth factors and their binding proteins: biological actions.  Endocr Rev. 1995;  16 3-34
    CrossrefPubMedSearch in Google Scholar
  • 21 Kostka T, Arsac L M, Patricot M C, Berthouze S E, Lacour J R, Bonnefoy M. Leg extensor power and dehydroepiandrosterone sulfate, insulin-like growth factor-I and testosterone in healthy active elderly people.  Eur J Appl Physiol. 2000;  82 83-90
    CrossrefPubMedSearch in Google Scholar
  • 22 Kraemer W J, Volek J S, Bush J A, Putukian M, Sebastianelli W J. Hormonal responses to consecutive days of heavy-resistance exercise with or without nutritional supplementation.  J Appl Physiol. 1998;  85 1544-1555
    PubMedSearch in Google Scholar
  • 23 Kunitomi M, Wada J, Takahashi K, Tsuchiyama Y, Mimura Y, Hida K, Miyatake N, Fujii M, Kira S, Shikata K, Maknio H. Relationship between reduced serum IGF‐I levels and accumulation of visceral fat in Japanese men.  Int J Obes Relat Metab Disord. 2002;  26 361-369
    CrossrefPubMedSearch in Google Scholar
  • 24 Lundvall J, Lindgren P. F-cell shift and protein loss strongly affect validity of PV reductions indicated by Hb/Hct and plasma proteins.  J Appl Physiol. 1998;  84 822-829
    PubMedSearch in Google Scholar
  • 25 Mohan S, Baylink D J, Pettis J L. Insulin-like growth factor (IGF)-binding proteins in serum - do they have additional roles besides modulating the endocrine IGF actions?.  J Clin Endocrinol Metab. 1996;  81 3817-3820
    CrossrefPubMedSearch in Google Scholar
  • 26 Nguyen U N, Mougin F, Simon-Rigaud M L, Rouillon J D, Marguet P, Regnard J. Influence of exercise duration on serum insulin-like growth factor and its binding proteins in athletes.  Eur J Appl Physiol. 1998;  78 533-537
    CrossrefPubMedSearch in Google Scholar
  • 27 Nindl B C, Kraemer W J, Marx J O, Arciero P J, Dohi K, Kellogg M D, Loomis G A. Overnight responses of the circulating IGF‐I system after acute, heavy-resistance exercise.  J Appl Physiol. 2001;  90 1319-1326
    PubMedSearch in Google Scholar
  • 28 Pruessner J C, Kirschbaum C, Meinlschmid G, Hellhammer D H. Two formulas for computation of the area under the curve represent measures of total hormone concentration versus time-dependent change.  Psychoneuroendocrinology. 2003;  28 916-931
    CrossrefPubMedSearch in Google Scholar
  • 29 Rosen C J. Insulin-like growth factor I and bone mineral density: experience from animal models and human observational studies.  Best Pract Res Clin Endocrinol Metab. 2004;  18 423-435
    CrossrefPubMedSearch in Google Scholar
  • 30 Rosendal L, Langberg H, Flyvbjerg A, Frystyk J, Orskov H, Kjaer M. Physical capacity influences the response of insulin-like growth factor and its binding proteins to training.  J Appl Physiol. 2002;  93 1669-1675
    PubMedSearch in Google Scholar
  • 31 Schwarz A J, Brasel J A, Hintz R L, Mohan S, Cooper D M. Acute effect of brief low- and high-intensity exercise on circulating insulin-like growth factor (IGF) I, II, and IGF-binding protein-3 and its proteolysis in young healthy men.  J Clin Endocrinol Metab. 1996;  81 3492-3497
    CrossrefPubMedSearch in Google Scholar
  • 32 Thissen J P, Ketelslegers J M, Underwood L E. Nutritional regulation of the insulin-like growth factors.  Endocr Rev. 1994;  15 80-101
    CrossrefPubMedSearch in Google Scholar
  • 33 Tissandier O, Peres G, Fiet J, Piette F. Testosterone, dehydroepiandrosterone, insulin-like growth factor 1, and insulin in sedentary and physically trained aged men.  Eur J Appl Physiol. 2001;  85 177-184
    PubMedSearch in Google Scholar
  • 34 Van Beaumont W. Evaluation of hemoconcentration from hematocrit measurements.  J Appl Physiol. 1972;  32 712-713
    PubMedSearch in Google Scholar

Dr. Jennifer L. Copeland

Department of Kinesiology
University of Lethbridge

4401 University Drive

T1K 3M4 Lethbridge

Canada

Phone: + 1 40 33 17 28 04

Fax: + 1 40 33 80 18 39

Email: jennifer.copeland@uleth.ca