Enantioselective Intramolecular Addition of Arylboronic Acids to Ketones

Significance

This work represents the first report on a Pd-catalyzed asymmetric arylation of simple ketones. It affords a simple technique for the highly enantioselective preparation of fused cyclo­alkanols. The products are useful intermediates in the synthesis of various biologically active molecules. This method has also good perspectives for a further development in order to perform an intermolecular version of this type of arylation reaction.