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Synfacts 2007(3): 0288-0288
DOI: 10.1055/s-2007-968274
DOI: 10.1055/s-2007-968274
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart · New York
Catalytic Asymmetric Friedel-Crafts Alkylation of Aromatic Ethers
J.-L. Zhao, L. Liu*, Y. Sui, Y.-L. Liu, D. Wang*, Y.-J. Chen*
Institute of Chemistry, Chinese Academy of Sciences, Beijing, P. R. of China
Further Information
Publication History
Publication Date:
20 February 2007 (online)
Significance
Over the past few years, the catalytic asymmetric Friedel-Crafts reaction has attracted great interest. In particular, its use in the synthesis of chiral aromatic hydroxy(trifluoromethyl) ethyl esters have been studied because of the possible biological properties of those compounds (W. Zhuang, N. Gathergood, R. G. Hazell, K. A. Jørgensen J. Org. Chem. 2001, 66, 1009-1013). In the present article, the authors report on ligand-free conditions to reach high yields and enantioselectivities.