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Synfacts 2007(4): 0342-0342  
DOI: 10.1055/s-2007-968288
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart · New York

Synthesis of (±)-Morphine

Contributor(s): Philip Kocienski, Stewart Eccles
K. Uchida, S. Yokoshima, T. Kan, T. Fukuyama*
The University of Tokyo and University of Shizuoka, Japan
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Publication History

Publication Date:
23 March 2007 (online)

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Significance

Noteworthy in this approach to a classic target is (1) the use of an intramolecular Heck reaction to install the quaternary center in E, and (2) the aldol-Michael cascade (E to F) which creates two rings.