Synthesis of Cytostatin

B. G. Lawhorn; S. B. Boga; S. E. Wolkenberg; D. A. Colby; C.-M. Gauss; M. R. Swingle; L. Amable; R. E. Honkanen; D. L. Boger

doi:10.1055/s-2007-968390

Subscribe to RSS

Please copy the URL and add it into your RSS Feed Reader.

https://www.thieme-connect.de/rss/thieme/en/10.1055-s-00000131.xml

Share / Bookmark

Facebook X Linkedin Weibo

Download PDF

Synfacts 2007(5): 0456-0456
DOI: 10.1055/s-2007-968390

Synthesis of Natural Products and Potential Drugs

Synthesis of Cytostatin

Contributor(s): Philip Kocienski, Fiona Black
B. G. Lawhorn, S. B. Boga, S. E. Wolkenberg, D. A. Colby, C.-M. Gauss, M. R. Swingle, L. Amable, R. E. Honkanen, D. L. Boger*
The Scripps Research Institute, La Jolla and University of South Alabama College of Medicine, Mobile, USA

Further Information

Publication History

Publication Date:
24 April 2007 (online)

Permissions and Reprints

Significance

A convergent synthesis of cytostatin and its C10 and C11 stereoisomers is reported which confirms the relative and absolute stereochemistry of this cytotoxic natural product. Several cytostatin analogues are also synthesized for biological evaluation.