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Synfacts 2007(5): 0463-0463
DOI: 10.1055/s-2007-968399
DOI: 10.1055/s-2007-968399
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart · New York
Synthesis of (+)-Rishirilide B
L. H. Mejorado, T. R. R. Pettus*
University of California, Santa Barbara, USA
Further Information
Publication History
Publication Date:
24 April 2007 (online)
Significance
(+)-Rishirilide B is a potent inhibitor of α2-macroglobulin, and may find use in the treatment of thrombosis. Key to this synthesis is the oxidative dearomatization of a functionalized phenol.