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Synfacts 2007(5): 0515-0515  
DOI: 10.1055/s-2007-968457
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart · New York

Diastereoselective Hydrogenation Using Chiral Crabtree-Type Catalysts

Contributor(s): Hisashi Yamamoto, Marina Naodovic
J. Zhou, K. Burgess*
Texas A & M University, College Station, USA
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Publication History

Publication Date:
24 April 2007 (online)

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Significance

In this report, the first truly diastereoselective hydrogenation of alkenes and dienes is presented. Products are obtained with high level of diastereoselectivity and possess interchangeable functionalities at the terminal positions. This method is a very efficient route to 2,4-dimethyl dyads and 2,4,6-trimethyl triads which can be found in a significant number of natural products.