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Synfacts 2007(5): 0554-0554  
DOI: 10.1055/s-2007-968479
Polymer-Supported Synthesis
© Georg Thieme Verlag Stuttgart · New York

Raney Cobalt Catalyzed Pauson-Khand Reaction

Contributor(s): Yasuhiro Uozumi, Yoichi M. A. Yamada
J.-L. Muller, A. Rickers, W. Leitner*
RWTH Aachen and Max Planck Institute of Coal Research, Mülheim an der Ruhr, Germany
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Publication History

Publication Date:
24 April 2007 (online)

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Significance

Commercially available Raney cobalt was applied to the intra- and intermolecular Pauson-Khand reaction. Thus, the reaction of 1a was performed with Raney cobalt under CO atmosphere in THF to give 2a in 94.5% conversion with 96.8% selectivity. The catalyst was reused five times with a slight loss of catalytic activity. Seven examples of the Pauson-Khand reaction were examined under similar conditions [Raney cobalt (6-16 mol%), CO (23-35 bar)] to afford cyclopentenones 2a-g with 54.2-99.5% conversion and 91.5-98.0% selectivity.