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Synfacts 2007(6): 0645-0645  
DOI: 10.1055/s-2007-968542
Metal-Mediated Synthesis
© Georg Thieme Verlag Stuttgart · New York

sp2- and sp3-C-H Bond Activation in Simple Carboxylic Acids

Contributor(s): Paul Knochel, Tobias Thaler
R. Giri, N. Maugel, J.-J. Li, D.-H. Wang, S. P. Breazzano, L. B. Saunders, J.-Q. Yu*
Brandeis University, Waltham, USA
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Publication History

Publication Date:
22 May 2007 (online)

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Significance

The first Pd-catalyzed C-H activation/C-C coupling reaction sequence using a carboxyl group is reported in this article. This method does not only allow the activation and coupling of sp2-C-H but even of sp3-C-H bonds. Protocols for C-H activation and subsequent Suzuki-type cross-coupling and for cross-coupling with aryl iodides are presented.