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Synfacts 2007(6): 0631-0631  
DOI: 10.1055/s-2007-968556
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart · New York

Ru-Catalyzed Asymmetric Diels-Alder Reactions with α,β-Unsaturated Ketones

Contributor(s): Mark Lautens, Yann Béthuel
J. Rickerby, M. Vallet, G. Bernardinelli, F. Viton, E. P. Kündig*
University of Geneva, Switzerland
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Publication History

Publication Date:
22 May 2007 (online)

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Significance

After the first report of a Lewis acid catalyzed enantioselective Diels-Alder reaction by Koga and co-workers (Chem. Commun. 1979, 437-438), extensive interest has been focused on improving the diastereo- and enantioselectivity of this reaction by changing the metal or the ligand. Herein, the authors apply their ‘one-point-bonding‘ ruthenium catalyst (Angew. Chem. Int. Ed. 1999, 38, 1220-1223) to new dienophiles.