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Synfacts 2007(7): 0751-0751  
DOI: 10.1055/s-2007-968643
Metal-Mediated Synthesis
© Georg Thieme Verlag Stuttgart · New York

C-H Functionalization via C-H Activation and C-C Bond Formation with Arylsilanes

Contributor(s): Paul Knochel, Tobias Thaler
S. Yang, B. Li, X. Wan, Z. Shi*
Peking University and State key Laboratory of organometallic Chemistry, Shanghai, P. R. of China
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Publication History

Publication Date:
22 June 2007 (online)

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Significance

A novel methodology for performing the ortho arylation of acetanilides via C-H activation and cross-coupling with trialkoxyarylsilanes is introduced. Cu(OTf)2 is hereby used as oxidant and AgF as fluoride source activating the trialkoxy­silanes for cross-coupling.