α-Aminoxylation of Aldehydes and Ketones with a Polymer-Supported Organocatalyst

Significance

The catalytic enantioselective α-aminoxylation of aldehydes and ketones by using polymer-supported organocatalyst 1 derived from trans-4-hydroxyproline was described. The reaction of aldehydes 2 with nitrosobenzene in the presence of catalyst 1 gave the aminoxylated products 3 which were readily transformed to the corresponding aminoxylated primary alcohols 4 in 35-86% yield and 96-99% ee (eq. 1). α-Aminoxylation of ketones 5 was also carried out in the presence of catalyst 1 to give the corresponding compounds 6 in 49-74% yield with 97-99% ee (eq. 2).