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Synfacts 2007(8): 0815-0815  
DOI: 10.1055/s-2007-968781
Synthesis of Materials and Unnatural Products
© Georg Thieme Verlag Stuttgart · New York

Template Synthesis of a 90-Membered Macrocycle

Contributor(s): Timothy M. Swager, Zhihua Chen
K. H. Song, S. O. Kang*, J. Ko*
Korea University, Chungham, Korea
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Publication History

Publication Date:
24 July 2007 (online)

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Significance

Ko and co-workers reported a facile synthesis of 90-membered macrocycle 4 by using hexaplatinum species based template 2, which is easily prepared from compound 1, a product of oxidative addition between Pt(PEt3)4 and hexakis(4-iodophenyl)hexaphenylbenzene. Olefin metathesis of 2 was performed in high dilution to suppress intermolecular reactions. Detachment of the resulting macrocycle from the template was achieved by treating 3 with aqueous NaI solution and a free macrocycle 4 was obtained after hydrogenolysis.