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Synfacts 2007(8): 0883-0883
DOI: 10.1055/s-2007-968810
DOI: 10.1055/s-2007-968810
Polymer-Supported Synthesis
© Georg Thieme Verlag Stuttgart · New York
PS-Supported Palladium-Phosphine Complexes
S. Schweizer, J.-M. Becht*, C. Le Drian*
Université de Haute-Alsace, Mulhouse, France
Further Information
Publication History
Publication Date:
24 July 2007 (online)
Significance
A series of polystyrene (PS) resin-supported palladium-triarylphosphine complexes were prepared. Various bis(substituted aryl)chlorophosphines 2a-j were prepared from the corresponding aryl bromide through metallation (Grignard or lithiation) and subsequent phosphorus substitution. The reaction of lithium phosphides of 2 with the Merrifield resin (Cl residue: 0.86 mmol/g) afforded PS-supported triarylphosphines 3. The catalytic potential of the resin-supported palladium-triarylphosphine complexes 4, which were generated from 3 and Pd(PPh3)4, were examined for the Suzuki-Miyaura coupling, the Sonogashira coupling, and Heck reactions.