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Synfacts 2007(9): 0966-0966  
DOI: 10.1055/s-2007-968850
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart · New York

Chiral Tertiary Alcohols by Addition of Organoaluminum Compounds

Contributor(s): Mark Lautens, Michael Langer
C.-A. Chen, K.-H. Wu, H.-M. Gau*
National Chung Hsing University, Taichung, Taiwan
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Publikationsdatum:
23. August 2007 (online)

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Significance

Synthesizing chiral tertiary alcohols derived from the corresponding ketones by enantio­selective addition of carbon nucleophiles is still a challenging task. The authors present a mild enantioselective addition of aryl groups to a variety of aromatic ketones and generate the corresponding tertiary alcohols in high yields and ee. Previous results of this group are described in K.-H. Wu, H.-M. Gau J. Am. Chem. Soc. 2006, 128, 14808.