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Synfacts 2007(9): 0966-0966
DOI: 10.1055/s-2007-968850
DOI: 10.1055/s-2007-968850
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart · New York
Chiral Tertiary Alcohols by Addition of Organoaluminum Compounds
C.-A. Chen, K.-H. Wu, H.-M. Gau*
National Chung Hsing University, Taichung, Taiwan
Further Information
Publication History
Publication Date:
23 August 2007 (online)
Significance
Synthesizing chiral tertiary alcohols derived from the corresponding ketones by enantioselective addition of carbon nucleophiles is still a challenging task. The authors present a mild enantioselective addition of aryl groups to a variety of aromatic ketones and generate the corresponding tertiary alcohols in high yields and ee. Previous results of this group are described in K.-H. Wu, H.-M. Gau J. Am. Chem. Soc. 2006, 128, 14808.