Neuroprotection in Parkinson's Disease: An Elusive Goal

Kevin M. Biglan; Bernard Ravina

doi:10.1055/s-2007-971168

Seminars in Neurology, Table of Contents

Semin Neurol 2007; 27(2): 106-112
DOI: 10.1055/s-2007-971168

Neuroprotection in Parkinson's Disease: An Elusive Goal

Kevin M. Biglan¹ , Bernard Ravina¹

¹Department of Neurology, University of Rochester School of Medicine and Dentistry, Rochester, New York

Abstract

ABSTRACT

Despite increases in our understanding of the pathophysiology and environmental and genetic influences of illness in Parkinson's disease, neuroprotection remains an elusive goal. No interventions are widely accepted as disease modifying in Parkinson's disease. Continued research identifying novel therapeutic targets is likely to result in several putative neuroprotective agents. Assimilating lessons from previous neuroprotection trials will be critical in developing future trials aimed at efficiently identifying neuroprotective treatments. Ultimately, overcoming the unique challenges of a heterogenous, slowly progressive disorder with multiple potential outcome measures will be necessary to identify treatments that have meaningful effects.

KEYWORDS

Neuroprotection - clinical trials - Parkinson's disease

Full Text

References

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Kevin M BiglanM.D. M.P.H.

Department of Neurology, University of Rochester School of Medicine and Dentistry

1351 Mt. Hope Avenue, Suite 223, Rochester, NY 14620