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DOI: 10.1055/s-2007-973899
Facile Synthetic Routes to 2-Oxo-1-adamantanalkanoic Acids
Publication History
Publication Date:
13 April 2007 (online)
Abstract
A simple, fast and efficient synthesis of 2-oxo-1-adamantanacetic acid and 2-oxo-1-adamantanepropanoic acid has been developed. All of the reactions described herein proceed cleanly, with high yields, and therefore offer a new pathway to the synthesis of 1,2-disubstituted adamantanes, which constitute starting materials for many molecules with pharmacological potential.
Key words
adamantane ketoacids - protoadamantanone - stereoselectivity - NMR
-
1a
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Optimized Procedure for the Preparation of Protoadamantanone
In an attempt to improve the yield of the literature procedure we modified the method as follows: After considerable experimentation we found that the percentage of the unreacted 1-adamantanol can be minimized by heating the reaction mixture [adamantanol, (MeCOO)4Pb, I2, C6H6] at 75-76 °C for 2 h. The resulting protoadamantanone is obtained almost pure and does not need further purification by column chromatography. [7a] -
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References and Notes
Manuscripts in preparation.
6
3-Oxatetracyclo[6.3.1.1
6,10
.0
²,6
]tridecan-4-one (
14)
Mp 92-93 °C. IR (mull): ν = 1789 (C=O) cm-1. 1H NMR (400 MHz, CDCl3): δ = 1.50 (br d, 1 H, J = 12.0 Hz, H-13e), 1.59-1.92 (complex m, 10 H, H-7, H-9, H-10, H-11, H-12, H-13a), 1.98-2.02 (m, 1 H, H-8), 2.11 and 2.21 (2 H, AB, J
AB
= 16.0 Hz, 5-H), 2.31 (d, 1 H, J = 4.0 Hz, H-1), 4.09 (d, 1 H, J = 4.0 Hz, H-2) ppm. 13C NMR (50 MHz, CDCl3): δ = 26.9 (C-10), 28.5 (C-8), 29.2 (C-11), 29.7 (C-1), 36.1 (C-13), 36.4 (C-9), 36.8 (C-12), 39.2 (C-7), 42.2 (C-6), 44.4 (C-5), 87.0 (C-2), 177.2 (C=O) ppm.
4-Hydroxytricyclo[4.3.1.0
³,8
]decan-4-acetic Acid (
12)
To a stirred solution of lithium bis(trimethylsilyl)amide (3.42 g, 19.6 mmol) in anhyd THF (55 mL) was added, over a period of 5 min, a solution of methyl acetate (1.45 g, 19.5 mmol) in anhyd THF (5 mL) at -75 °C under an argon atmosphere. After stirring the mixture for 20 min, a solution of protoadamantanone (10, 1.48 g, 9.8 mmol) in anhyd THF (10 mL) was added and the resulting suspension was stirred for 30 min at -60 °C. The mixture was treated with ice-water (15 mL), extracted with Et2O (2 × 20 mL) and the organic phase was washed with H2O (10 mL), HCl 5% (10 mL), H2O (10 mL), dried (Na2SO4) and concentrated in vacuo. The oily residue was saponified with NaOH (0.8 g, 20 mmol) EtOH-H2O (15 mL, 1:1) solution over 24 h at r.t. After evaporation of the solvent, the mixture was extracted twice with Et2O (20 mL). The aqueous layer was acidified with concd HCl under cooling (0 °C). The white solid hydroxyacid formed was filtered off, washed with H2O and dried (1.85 g, 95%); mp 185 °C (dec.; THF-n-pentane). IR (mull): ν = 3255 (OH), 1706 (C=O) cm-1. 1H NMR (400 MHz, DMSO): δ = 1.18-1.85 (complex m, 9 H, H-2, H-5, H-7, H-9e, H-10), 1.89 (br s, 1 H, H-6), 2.06 (br s, 1 H, H-1), 2.16-2.29 (m, 3 H, H-3, H-8, H-9a), 2.36 and 2.46 (2 H, AB, J
AB
= 14.0 Hz, CHA, CHB) ppm. 13C NMR (50 MHz, DMSO): δ = 29.1 (C-6), 32.9 (C-9), 34.3 (C-8), 36.0 (C-2), 36.3 (C-1), 40.5 (C-10), 42.6 (C-7), 42.9 (C-5), 45.6 (C-3), 48.7 (CH2COOH), 73.6 (C-4), 174.2 (C=O) ppm. Anal. Calcd for C12H18O3: C, 68.54; H, 8.63. Found: C, 68.19; H, 8.28.
2-Hydroxy-1-tricyclo[3.3.1.1
³,7
]decanacetic Acid (
15)
A solution of 4-hydroxytricyclo[4.3.1.03,8]decan-4-acetic acid (12, 1.48 g, 7.0 mmol) in formic acid (20 mL) was refluxed for 30 min. After removal of formic acid under reduced pressure a viscous oil was obtained, which consisted of formic ester 13 (major product) and lactone 14 (minor product). The mixture was saponified with NaOH (1.80 g, 45.0 mmol) EtOH-H2O (20 mL, 1:1) solution over 2.5 h in a boiling steam bath. After evaporation of EtOH, the aqueous layer was acidified with concd HCl to pH 3 under cooling (0 °C). The white solid hydroxyacid formed was filtered off, washed with H2O and dried (1.28 g, 87%); mp 119 °C (dec.; Et2O-n-pentane). IR (mull): ν = 3455 (OH), 1702 (C=O) cm-1. 1H NMR (400 MHz, CDCl3): δ = 1.34 (br d, 1 H, J = 12.0 Hz, H-9e), 1.46 (br d, 1 H, J = 12.0 Hz, H-4e), 1.58-1.80 (complex m, 7 H, H-6, H-8, H-10, OH), 1.89 (br s, 2 H, H-5, H-7), 1.95-1.98 (m, 3 H, H-3, H-4a, H-9a), 2.16 and 2.37 (2 H, AB, J
AB
= 13.0 Hz, CHA, CHB), 3.74 (s, 1 H, H-2) ppm. 13C NMR (50 MHz, CDCl3): δ = 27.9 (C-5), 28.0 (C-7), 30.2 (C-4), 34.8 (C-3), 36.3 (C-9), 36.4 (C-6), 36.6 (C-10), 37.2 (C-1), 41.6 (C-8), 45.2 (CH2COOH), 76.3 (C-2), 177.5 (C=O) ppm. Anal. Calcd for C12H18O3: C, 68.54; H, 8.63. Found: C, 68.32; H, 8.38.
2-Oxo-1-tricyclo[3.3.1.1
³,7
]decanacetic Acid (
9)
To a solution of hydroxyacid 15 (1.11 g, 5.2 mmol) in acetone (40 mL) was added, during a 30 min period, Jones reagent (12 mL, 1 M) at 15 °C. After stirring for 24 h at ambient temperature, i-PrOH (3 mL) was added, and stirring was continued for an additional 1 h. The reaction mixture was filtered off and the filtrate was evaporated in vacuo. Then, H2O (10 mL) was added and the mixture was cooled to form a precipitate which was filtered off and washed with cold H2O to give ketoacid 9 (1.00 g, 92%) as a white solid; mp 145-146 °C (lit.: 145-146 °C). IR (mull): ν 1715 (C=O), 1700 (C=O) cm-1. 1H NMR (400 MHz, CDCl3): δ = 1.84-2.09 (complex m, 12 H, H-4, H-5, H-6, H-7, H-8, H-9, H-10), 2.39 (s, 2 H, -CH
2
COOH), 2.61 (br s, 1 H, H-3), 11.24 (br s, 1 H, -COOH) ppm. 13C NMR (50 MHz, CDCl3):
δ = 27.8 (C-5, C-7), 35.4 (C-6), 39.0 (C-4, 10), 41.1
(-CH2COOH), 43.9 (C-8, C-9), 46.5 (C-3), 48.6 (C-1), 176.5 (-COOH), 217.3 (C-2) ppm. Anal. Calcd for C12H16O3: C, 69.21; H, 7.74. Found: C, 69.33; H, 7.80.
4-Hydroxy-4-tricyclo[4.3.1.0
³,8
]decane-2-propynol (
22)
A solution of propargyl alcohol (2.06 g, 36.8 mmol) in anhyd THF (20 mL) was added dropwise to a solution of EtMgBr [prepared by the addition of a solution of ethyl bromide (8.00 g, 73.0 mmol) in anhyd THF (65 mL) to magnesium turnings (1.6 g, 66 mmol)] and the mixture was stirred for 1 h at 20 °C. Then a solution of protoadamantanone (10, 2.00 g, 13.3 mmol) in anhyd THF (20 mL) was added and the mixture was refluxed for 6 h. After stirring for 24 h at 20 °C, the mixture was hydrolyzed under ice cooling by the addition of sat. NH4Cl solution. The aqueous phase was extracted with Et2O (3 × 20 mL) and the combined organic extracts were washed with H2O (3 × 20 mL) and dried (Na2SO4). The solvent was evaporated in vacuo and the residue formed was crystallized upon treatment with a mixture of Et2O-PE. The solid was filtered off and washed with a cold mixture of PE-Et2O (2.5:1) to give diol 22 (2,23 g, 82%) as a white solid; mp 106 °C (Et2O-n-pentane). IR (mull): ν = 3278 (OH), 2361 cm-1.1H NMR (400 MHz, CDCl3): δ (endo/exo, 1:1) = 1.29-1.42 (m, 2 H, H-9e, H-10a), 1.45-1.51 (m, 1 H, H-7a), 1.60-2.18 (complex m, 9 H, H-2, H-5, H-6, H-7e, H-8, H-9a, H-10e), 2.25-2.39 (complex m, 1 H, H-1), 2.44-2.49 (m, 1 H, H-3), 2.74 (br s, 2 H, 2 × OH), 4.29 (s, 2 H, -CH
2
OH) ppm. 13C NMR (50 MHz, CDCl3): δ = 28.2/29.0 (C-6), 31.5/31.6 (C-9), 32.8/34.1 (C-8), 35.4/35.6 (C-1), 36.1/36.2 (C-2), 39.4/39.9 (C-10), 42.1/42.5 (C-7), 43.2/44.5 (C-5), 46.8/47.7 (C-3), 51.0 (-CH2OH), 68.2 (-CºC-CH2OH), 70.6 (-CºC-CH2OH), 80.0/80.7 (4-C) ppm. Anal. Calcd for C13H18O2: C, 75.69; H, 8.79. Found: C, 75.87; H, 8.98.
2-Hydroxy-1-tricyclo[3.3.1.1
³,7
]decanepropanol (
21)
A solution of diol 23 (0.88 g, 4.2 mmol) in formic acid (15 mL) was refluxed for 30 min. After removal in vacuo of formic acid an oil residue was obtained (diester 24), which was saponified with NaOH (1.90 g, 47.5 mmol) EtOH-H2O (15 mL, 1:1) solution over 2 h in a boiling steam bath. After evaporation of EtOH, the mixture was extracted with Et2O, the combined organic extracts were dried (Na2SO4) and the solvent was evaporated in vacuo. The residue was purified by flash column chromatography using as eluents Et2O and Et2O-MeOH (1:1) to afford 2-hydroxy-1-tri-cyc-lo[3.3.1.13,7]decanepropanol (21) as a white solid (0.71 g, 81%); mp 99 °C (Et2O). IR (mull): ν = 3322 (OH) cm-1. 1H NMR (400 MHz, CDCl3): δ = 1.10-1.15 (m, 1 H, H-9e), 1.25 (d, 1 H, CH
A
CH2CH2OH), 1.36-1.97 (complex m, 15 H, H-3, H-4a, H-4e, H-5, H-6, H-7, H-8, H-9a, H-10, CH
B
CH2CH2OH, CH
2
CH2OH), 2.31 (s, 2 H, 2 × OH), 3.65-3.69 (complex m, 3 H, H-2, -CH
2
OH) ppm. 13C NMR (50 MHz, CDCl3): δ = 25.1 (CH2CH2OH), 28.0 (C-5), 28.1 (C-7), 30.8 (C-4), 35.0 (C-3), 35.1 (C-9), 36.2 (C-1), 36.7 (C-6), 37.2 (CH2CH2CH2OH), 37.3 (C-10), 40.4 (CH2
CH2CH2OH), 63.6 (CH2OH), 75.8 (C-2) ppm. Anal. Calcd for C13H22O2: C, 74.24; H, 10.54. Found: C, 74.03; H, 10.42.
2-Oxo-1-tricyclo[3.3.1.1
³,7
]decanopropanoic Acid (
25)
To a solution of diol 21 (2.24 g, 10.6 mmol) in acetone (80 mL) was added, during a 1.5 h period, Jones reagent (34.8 mL, 1 M) under ice cooling. After stirring for 24 h at ambient temperature, i-PrOH (3 mL) was added and stirring was continued for an additional 1 h. The reaction mixture was filtered off and the filtrate was evaporated in vacuo. Then, H2O (10 mL) was added to the residue and the mixture was extracted with Et2O (3 × 20 mL). The combined organic extracts were washed with H2O (2 × 10 mL), dried (Na2SO4), concentrated in vacuo and the residue formed treated with PE. The solution was cooled to -15 °C and the precipitate formed was filtered off and washed with cold PE (-15 °C) to afford ketoacid 25 (2.30 g, quantitative yield) as a white solid; mp 115-117 °C (Et2O-n-hexane). IR (mull): ν = 1737 (C=O), 1683 (C=O) cm-1. 1H NMR (400 MHz, CDCl3): δ = 1.66-1.70 (t, 2 H, J = 8.4 Hz, CH
2
CH2COOH), 1.79-2.01 (complex m, 10 H, H-4, H-6, H-8, H-9, H-10), 2.07 (br s, 2 H, H-5, H-7), 2.37-2.41 (t, 2 H, J = 8.1 Hz, -CH
2
COOH), 2.52 (br s, 1 H, H-3) ppm. 13C NMR (50 MHz, CDCl3): δ = 27.9 (C-5, C-7), 28.6 (-CH2COOH), 31.0
(-CH2CH2COOH), 35.8 (C-8, C-10), 39.1 (C-4, C-9), 44.0 (C-6), 46.9 (C-3), 48.7 (C-1), 180.1 (-COOH), 217.7 (C=O) ppm. Anal. Calcd for C13H18O3: C, 70.24; H, 8.16. Found: C, 70.03; H, 7.95.