Abstract
In addition to their C8-N H-arylamine-dG counterparts, C8-N -acetylarylamine adducts of 2′-deoxyguanosine (2′-dG) play an important role in the
possible induction of chemical carcinogenesis. A new synthetic pathway of this adduct
type using different aromatic amines has been developed following most probably an
electrophilic amination reaction. These adducts can be converted into the corresponding
phosphoramidites for incorporation into oligonucleotides.
Key words
arylamines - DNA damage - electrophilic addition - C8-N -Ac-dG adducts
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