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Synfacts 2008(1): 0087-0087  
DOI: 10.1055/s-2007-991440
Metal-Mediated Synthesis
© Georg Thieme Verlag Stuttgart · New York

One-Pot Multicatalytic Processes Combining Methylenation and Cross-Coupling Reactions

Contributor(s): Paul Knochel, Tobias Thaler
H. Lebel*, C. Ladjel, L. Bréthous
Université de Montréal, Canada
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Publication History

Publication Date:
18 December 2007 (online)

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Significance

This article underlines the usefulness of Cu(I)- and Rh(I)-catalyzed methylenation reactions of aldehydes for one-pot procedures. The methylenation reaction is combined with different coupling reactions in several sequences, such as methylenation-Heck cross-coupling, and methylenation-hydroboration-Suzuki cross-coupling. The Cu(I) complex used as catalyst for the methylenation reaction was found to also exert a beneficial cocatalytic effect on the subsequent cross-coupling reactions.