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Synfacts 2008(1): 0102-0102  
DOI: 10.1055/s-2007-991456
Polymer-Supported Synthesis
© Georg Thieme Verlag Stuttgart · New York

Synthesis of a Library of Imidazolin-4-ones Using PEG-4000

Contributor(s): Yasuhiro Uozumi, Hiroe Takenaka
H.-X. Li, C. Xie, M.-W. Ding*, Z.-M. Liu, G.-F. Yang*
Central china normal university, Wuhan, P. R. of China
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Publication History

Publication Date:
18 December 2007 (online)

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Significance

A library of imidazolin-4-one has been synthesized using poly(ethylene glycol) as a soluble polymer support. The PEG-supported imino­phosphorane 3 was prepared in three steps from PEG-4000. The PEG-supported carbodi­imides 4 were obtained via the intermolecular aza-Wittig reaction of PEG-supported iminophosphorane 3 with aromatic isocyanates. The PEG-supported carbodiimides 4 reacted with primary amines in dichloromethane to give the desired imidazolin-4-ones 6 or 7.