Abstract
We describe a synthetic pathway to structurally complex and diverse polyketides based, in part, on regio- and stereoselective titanium-mediated coupling reactions. The sequences described allow for rapid assembly of polyketide-inspired architecture while providing significant flexibility for the establishment of diverse stereochemical relationships and substitution patterns along the carbon backbone (including stereodefined alkenes and 1,3-dienes, saturated and unsaturated lactones, hemiketals, α,β-unsaturated carbonyls, and spiroketals).
Keywords
polyketides - diversity-oriented synthesis - alkyne complexes - titanium - cross-coupling - regioselectivity
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