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Synfacts 2008(3): 0231-0231
DOI: 10.1055/s-2008-1042652
DOI: 10.1055/s-2008-1042652
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart · New York
Synthesis of (+)-Spirolaxine Methyl Ether
B. M. Trost*, A. H. Weiss
Stanford University, USA
Further Information
Publication History
Publication Date:
21 February 2008 (online)
Significance
The spirolaxine family was isolated from Sporotichum laxum and has shown several different biological activities including potent activity against Helicobacter pylori. This synthesis of spirolaxine methyl ether features an efficient asymmetric alkynylation (A→D) catalyzed by the phenol C.