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Synfacts 2008(3): 0270-0270  
DOI: 10.1055/s-2008-1042685
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart · New York

Palladium-Catalyzed Arylation of Silylphosphines

Contributor(s): Hisashi Yamamoto, Marina Naodovic
V. S. Chan, R. G. Bergman*, F. D. Toste*
University of California, Berkeley, USA
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Publikationsverlauf

Publikationsdatum:
21. Februar 2008 (online)

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Significance

P-Stereogenic phosphines are recognized as very efficient ligands for transition-metal-catalyzed transformations. Still, examples of their utility are scarce due to the lack of efficient synthetic methods for their preparation. This account describes a novel approach to the preparation of these phosphines via dynamic enantioselective arylation of silylphosphine substrates.