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Synfacts 2008(3): 0288-0288
DOI: 10.1055/s-2008-1042696
DOI: 10.1055/s-2008-1042696
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart · New York
Nickel-Catalyzed Regioselective Olefin-Directed Cross-Coupling Reaction
R. L. Rogers, J. L. Moore, T. Rovis*
Colorado State University, Fort Collins, USA
Further Information
Publication History
Publication Date:
21 February 2008 (online)
Significance
The development of an efficient catalytic regioselective alkylation of cyclic anhydrides through olefin-directed nickel insertion and subsequent cross-coupling is reported. The corresponding alkylated products are obtained in good yields and regioselectivities.