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Synfacts 2008(3): 0292-0292
DOI: 10.1055/s-2008-1042734
DOI: 10.1055/s-2008-1042734
Metal-Mediated Synthesis
© Georg Thieme Verlag Stuttgart · New York
Simple and Universal Pd(II) Precatalyst for the Suzuki-Miyaura Cross-Couplings
M. J. Burns, I. J. S. Fairlamb*, A. R. Kapdi, P. Sehnal, R. J. K. Taylor*
University of York, UK
Further Information
Publication History
Publication Date:
21 February 2008 (online)
Significance
Catalytic C-C bond-forming processes are among the most important reactions in the contemporary organic synthesis. Herein, the authors demonstrated the feasibility and high activity of the readily available, commercial compound PdBr(N-Succ)(PPh3)2 (1) in a number of Suzuki-Miyaura cross-coupling reactions. Aryl and benzylic halides as well as 2-iodoenones in the presence of this catalyst can be readily coupled with aryl-, hetaryl- and alkenylboronic acids, including those prone to protodeborylation. The catalyst can be efficiently recycled, using a polyethylene oxide additive.