Download PDF
Synfacts 2008(4): 0396-0396  
DOI: 10.1055/s-2008-1042791
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart · New York

N,N′-Dioxide-Sc(III) Catalyst for Enantioselective Aza-Diels-Alder Reaction

Contributor(s): Mark Lautens, Valentina Aureggi
D. Shang, J. Xin, Y. Liu, X. Zhou, X. Liu, X. Feng*
Sichuan University, Chengdu, P. R. of China
Further Information

Publication History

Publication Date:
19 March 2008 (online)

    Permissions and Reprints

Significance

The development of a new chiral l-proline-derived N,N′-dioxide-scandium(III) catalyst for an efficient enantioselective aza-Diels-Alder reaction is reported. The corresponding 2,5-disubstituted dihydropyridinone products, from aldimines and a Danishefsky-type diene, are obtained with up to 92% yield and 92% ee.