Download PDF
Synfacts 2008(4): 0409-0409  
DOI: 10.1055/s-2008-1042817
Metal-Mediated Synthesis
© Georg Thieme Verlag Stuttgart · New York

Tandem Palladium-Catalyzed Amination and Heck-Coupling Reaction for Indole Synthesis

Contributor(s): Paul Knochel, Tobias Thaler
Y.-Q. Fang, M. Lautens*
University of Toronto, Canada
Further Information

Publication History

Publication Date:
19 March 2008 (online)

    Permissions and Reprints

Significance

A highly efficient synthesis of functionalized indoles via tandem Buchwald-Hartwig amination and Suzuki cross-coupling is reported. This method displays high functional group tolerance, easy accessibility of the starting materials, and variability of the respective boron reagents.