Efficient Palladium-Catalyzed Synthesis of Aminopyridyl Phosphonates from Bromopyridines and Diethyl Phosphite

Alla Bessmertnykh; Christiane Morkos Douaihy; Sankar Muniappan; Roger Guilard

doi:10.1055/s-2008-1072570

PAPER

Efficient Palladium-Catalyzed Synthesis of Aminopyridyl Phosphonates from Bromopyridines and Diethyl Phosphite

Alla Bessmertnykh, Christiane Morkos Douaihy, Sankar Muniappan, Roger Guilard*
Institut de Chimie Moléculaire, Université de Bourgogne (ICMUB) - UMR 5260 CNRS, 9, av. Alain Savary, 21078 Dijon, France
Fax: +33(3)80396138; e-Mail: Roger.Guilard@u-bourgogne.fr;

Abstract

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Abstract

A general method for coupling aminopyridyl bromides with diethyl phosphite is reported. This efficient route is realized through the use of a palladium catalyst and triethylamine as base.

Key words

palladium - catalysis - phosphonates - cross-coupling - pyridyl halides

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References

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