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Synfacts 2008(6): 0555-0555  
DOI: 10.1055/s-2008-1072610
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart · New York

Formal Synthesis of (-)-Platensimycin

Contributor(s): Philip Kocienski, Zofia Komsta
K. C. Nicolaou*, D. Pappo, K. Y. Tsang, R. Gibe, D. Y.-K. Chen*
A*STAR, Singapore; The Scripps Research Institute and University of California, La Jolla, USA
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Publication History

Publication Date:
21 May 2008 (online)

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Significance

(-)-Platensimycin was isolated from a strain of Streptomyces platensis. It belongs to a new structural class of antibiotics that inhibits bacterial biosynthesis of fatty acids through binding to the acyl-enzyme intermediate of the elongation-condensing enzyme FabF. For the completion of the synthesis of (-)-platensimycin from the intermediate H, see: K. C. Nicolaou, A. Li, D. J. Edmonds Angew. Chem. Int. Ed. 2006, 45, 7086.