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Synfacts 2008(6): 0604-0604  
DOI: 10.1055/s-2008-1072622
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart · New York

Enantioselective Hydrosilylation of Ketones Catalyzed by Chiral Phosphine/Iron Complex

Contributor(s): Hisashi Yamamoto, Pingfan Li
N. S. Shaikh, S. Enthaler, K. Junge, M. Beller*
Leibniz-Institut für Katalyse e.V. an der Universität Rostock, Germany
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Publikationsverlauf

Publikationsdatum:
21. Mai 2008 (online)

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Significance

Systematic investigation of ligands, iron source, silane reagents, solvents and reaction temperatures led to the preparation of various secondary alcohol products via asymmetric iron-catalyzed hydrosilylation of ketones in good yield and good to excellent enantiomeric excess.