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Synfacts 2008(8): 0886-0886  
DOI: 10.1055/s-2008-1077932
Polymer-Supported Synthesis
© Georg Thieme Verlag Stuttgart ˙ New York

PS-BEMP-Catalyzed Michael Addition

Contributor(s): Yasuhiro Uozumi, Yoshinori Hirai
R. Ballini, L. Barboni, L. Castrica, F. Fringuelli, D. Lanari, F. Pizzo*, L. Vaccaro*
Università di Camerino and Università di Perugia, Italy
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Publication History

Publication Date:
23 July 2008 (online)

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Significance

2-tert-Butylimino-2-diethylamino-1,3-dimethylperhydro-1,3,2-diazaphosphorine anchored on polystyrene (PS-BEMP) catalyzed the addition of nitroalkanes to α,β-unsaturated carbonyl compounds. Thus, Michael addition of nitromethane to α,β-unsaturated carbonyl compounds was carried out with 5 mol% of PS-BEMP under solvent-free conditions to give the corresponding γ-nitro compounds in 76-95% yield (14 examples).