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Synfacts 2008(10): 1081-1081  
DOI: 10.1055/s-2008-1078130
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart ˙ New York

Catalytic Enantioselective Conjugate Additions with N,N,P-Tridentate Ligands

Contributor(s): Mark Lautens, Frédéric Ménard
K. Kawamura, H. Fukuzawa, M. Hayashi*
Kobe University, Japan
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Publication History

Publication Date:
22 September 2008 (online)

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Significance

The development of asymmetric additions to Michael acceptors has matured to a state where many catalytic systems can effect this transformation with high enantioselectivity. The challenges now lie in achieving high catalyst efficiency. The new N,N,P-tridentate ligand reported forms a highly active Cu(II) catalyst that can be used at loadings as low as 0.1%.