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Synfacts 2008(10): 1015-1015  
DOI: 10.1055/s-2008-1078188
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart ˙ New York

Synthesis of Ethyl Deoxymonate B

Contributor(s): Philip Kocienski, Stewart Eccles
R. Fernández de la Pradilla*, N. Lwoff
CSIC, Madrid, Spain
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Publication History

Publication Date:
22 September 2008 (online)

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Significance

Ethyl deoxymonate B is a precursor to pseudomonic acid B, a member of the pseudomonic acid family of antibiotics. The pyran core was synthesized by a base-promoted diastereoselective addition of an alkoxide to the α,β-unsaturated sulfoxide C to give a 2,3-trans-sulfinyl dihydropyran.