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Synfacts 2008(10): 1121-1121  
DOI: 10.1055/s-2008-1078197
Polymer-Supported Synthesis
© Georg Thieme Verlag Stuttgart ˙ New York

[3+2] Cycloaddition Catalyzed by Cu(I)-Zeolites

Contributor(s): Yasuhiro Uozumi, Go Hamasaka
S. Chassaing, A. S. S. Sido, A. Alix, M. Kumarraja, P. Pale*, J. Sommer*
Université de Strasbourg, France
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Publication History

Publication Date:
22 September 2008 (online)

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Significance

Cu(I)-zeolites catalyze the Huisgen [3+2] cycloaddition of alkynes 1 and azides 2. Thus, the [3+2] cycloaddition of terminal alkynes 1 with azides 2 was carried out in the presence of Cu(I)-USY to give the corresponding 1,4-disubstituted 1,2,3-triazoles 3 in 0-94% yield. The catalyst was recycled three times without significant loss of catalytic activity.