PDF herunterladen
Synfacts 2008(8): 0792-0792  
DOI: 10.1055/s-2008-1078530
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart ˙ New York

Synthesis of (-)-Platencin

Contributor(s): Philip Kocienski, Zofia Komsta
K. C. Nicolaou*, G. S. Tria, D. J. Edmonds
The Scripps Research Institute, La Jolla and The University of California, San Diego, USA
Weitere Informationen

Publikationsverlauf

Publikationsdatum:
23. Juli 2008 (online)

    Lizenzen und Reprints

Significance

Platencin was isolated from a strain of Streptomyces platensis. Due to its novel mechanism of an action, platensin may offer a treatment for drug-resistant bacterial infections. It exhibits micromolar activity against many gram-positive pathogens, including methycillin and vancomycin resistant strains. The first enantioselective synthesis is presented.