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Synfacts 2008(9): 0999-0999  
DOI: 10.1055/s-2008-1078661
Polymer-Supported Synthesis
© Georg Thieme Verlag Stuttgart ˙ New York

Sonogashira Reaction Catalyzed by Cobalt Hollow Nanospheres

Contributor(s): Yasuhiro Uozumi, Yutaka Matsuura
L. Feng, F. Liu, P. Sun*, J. Bao*
Nanjing Normal University, P. R. of China
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Publikationsdatum:
22. August 2008 (online)

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Significance

The Sonogashira reaction of various aryl halides 1 with terminal alkynes 2 took place in the presence of cobalt hollow nanospheres, potassium carbonate, triphenylphosphine, and copper iodide in N-methyl-2-pyrrolidone (NMP) to give the corresponding products 3 in up to 90% yield (15 examples). This catalyst was separated from the reaction mixture by centrifugation, and reused three times in the Sonogashira reaction of 4-iodotoluene and phenylacetylene (80-83% yield).