Zusammenfassung
Multi-Spezies-Probiotika kombinieren die spezifischen Eigenschaften von verschiedenen
Bakterien-Gattungen, -Arten oder -Stämmen miteinander und können im Idealfall synergistisch
wirken. Auf (immuno)pathophysiologischer Grundlage wird das Design krankheitsspezifischer
Multi-Spezies-Probiotika zur Vorbeugung vor Allergien im Kindesalter und Asthma beschrieben.
Ein nach diesen Kriterien konzipiertes Handelspräparat aus Bifidobacterium bifidum,
B. infantis und Lactobacillus lactis führte nach perinataler Verabreichung zu einer
erheblichen Verringerung von Ekzemen in den ersten 3 Monaten nach der Geburt. Die
Wirkung hielt auch darüber hinaus an. Es bleibt offen, ob dieses Probiotikum auch
eine erfolgreiche Reduzierung von Asthma-Anfällen herbeiführen kann.
Summary
A literature survey was carried out to compare functionality and efficacy of monostrain,
multistrain and multispecies probiotics. Multispecies probiotics offer the opportunity
to combine genus, species or strain-specific properties and may provide synergistic
effects. Through a combination of strains with distinct health-promoting properties,
diseasespecific multispecies probiotics can be designed that tackle various pathophysiological
aspects simultaneously. The design of a disease-specific multispecies probiotic for
prevention of childhood allergy and asthma is described based on the (immuno)pathophysiological
events in asthma and allergy. We have selected a commercially available multispecies
probiotic consisting of Bifidobacterium bifidum, B. infantis and Lactobacillus lactis).
Perinatal administration of this probiotic mixture significantly reduced the amount
of eczema during the first 3 months of life when compared to placebo. The protective
effects are sustained during the first years but it remains to be seen whether this
protocol is able to reduce the incidence of asthma.
Schlüsselwörter
Probiotika - Multi-Spezies-Probiotikum - Allergie - Asthma
Key words
Probiotic - Monostrain - Multistrain - Multispecies - Allergy - asthma
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Dr. Harro M. Timmerman
Winclove Bio Industries BV
Postbus 37239
1030 AE Amsterdam
Niederlande
eMail: Harro.timmerman@gmail.com
