Polymorphisms in Perilipin Gene (PLIN) are not Associated with Obesity and Weight Variation in People with High Risk of Type 2 Diabetes

Abstract

Perilipins are hormonally regulated phosphorylated proteins that coat the intracellular lipid storage droplet [1]. They are essential for the regulation of triglyceride deposition and mobilization [2] [3]. The human perilipin gene (PLIN) is located to 15q26.1, near the susceptibility loci for obesity, and insulin-dependent diabetes mellitus, and hypertriglyceridemia. Therefore, it is considered as a candidate gene for these diseases [4]. Some studies shown that lower level of perilipin protein was displayed in obese than lean subjects [5] and polymorphisms in PLIN were associated with obesity in American and Spanish white women as well as in Korean [6] [7]. But some other studies showed that, this association was not significant in Chinese [8] and French [9]. The aim of the current study was to examine whether the associations manifested in a German population with high risk of type 2 diabetes.

Key words

perilipin - obesity - weight change

References

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1 These authors contributed equally to this work.

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