The structural basis for the pathophysiological relevance of PAI-1 in cardiovascular diseases and the development of potential PAI-1 inhibitors

Ann Gils; Paul J. Declerck

doi:10.1160/TH03-12-0764

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 2004; 91(03): 425-437
DOI: 10.1160/TH03-12-0764

Theme Issue Review Article

Schattauer GmbH

The structural basis for the pathophysiological relevance of PAI-1 in cardiovascular diseases and the development of potential PAI-1 inhibitors

Ann Gils

¹Laboratory for Pharmaceutical Biology and Phytopharmacology, K. U. Leuven, Leuven, Belgium

,

Paul J. Declerck

¹Laboratory for Pharmaceutical Biology and Phytopharmacology, K. U. Leuven, Leuven, Belgium

› Author Affiliations

Abstract

Summary

Plasminogen activator inhibitor-1 (PAI-1) is an important component of the plasminogen/plasmin system as it is the main inhibitor of tissue-type and urokinase-type plasminogen activator. Consequently, PAI-1 plays an important role in cardiovascular diseases (mainly through inhibition of t-PA), and in cell migration and tumor development (mainly through inhibition of u-PA and interaction with vitronectin). As a member of the serpin superfamily, PAI-1 shares important structural properties with other serpins. However, PAI-1 also exhibits unique conformational and functional properties. The current review provides an overview of the knowledge on PAI-1 gathered since its discovery two decades ago. We discuss (a) its structural properties of the protein and their subsequent relation to functional activities, (b) its role in a wide variety of (patho) physiological processes and (c) a number of strategies to interfere with its functional properties eventually aiming at pharmacological modulation of this risk factor.

Keywords

PAI-1 - serpin - fibrinolysis - thrombosis

Full Text

References

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