Protein C inhibitor, a serpin with functions in- and outside vascular biology

Margarethe Geiger

doi:10.1160/TH06-09-0488

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 2007; 97(03): 343-347
DOI: 10.1160/TH06-09-0488

Theme Issue Article

Schattauer GmbH

Protein C inhibitor, a serpin with functions in- and outside vascular biology

Margarethe Geiger

¹Department of Vascular Biology and Thrombosis Research, Center for Biomolecular Medicine and Pharmacology, Medical University of Vienna, Vienna, Austria

› Author Affiliations

Abstract

Summary

Human protein C inhibitor (PCI), a serpin-type protease inhibitor originally described as an inhibitor of activated protein C, has broad protease reactivity. In addition to its activities within the blood clotting and fibrinolytic cascades, it seems to participate in several biological processes including reproductiorn and tumor growth. This review summarizes the current understanding of PCI function, regulation, and potential biological role.

Keywords

Serpins - phospholipids - proteases

Full Text

References

References
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