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DOI: 10.1160/th14-04-0311
In vivo activation and functions of the protease factor XII
Publication History
Received:
03 April 2014
Accepted after major revision:
07 July 2014
Publication Date:
20 November 2017 (online)
Summary
Combinations of proinflammatory and procoagulant reactions are the unifying principle for a variety of disorders affecting the cardiovascular system. Factor XII (FXII, Hageman factor) is a plasma protease that initiates the contact system. The biochemistry of the contact system in vitro is well understood; however, its in vivo functions are just beginning to emerge. The current review concentrates on activators and functions of the FXII-driven contact system in vivo. Elucidating its physiologic activities offers the exciting opportunity to develop strategies for the safe interference with both thrombotic and inflammatory diseases.
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